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Adam Frank

Adam Frank

3 years ago

Humanity is not even a Type 1 civilization. What might a Type 3 be capable of?

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Michael Hunter, MD

Michael Hunter, MD

3 years ago

5 Drugs That May Increase Your Risk of Dementia

Photo by danilo.alvesd on Unsplash

While our genes can't be changed easily, you can avoid some dementia risk factors. Today we discuss dementia and five drugs that may increase risk.

Memory loss appears to come with age, but we're not talking about forgetfulness. Sometimes losing your car keys isn't an indication of dementia. Dementia impairs the capacity to think, remember, or make judgments. Dementia hinders daily tasks.

Alzheimers is the most common dementia. Dementia is not normal aging, unlike forgetfulness. Aging increases the risk of Alzheimer's and other dementias. A family history of the illness increases your risk, according to the Mayo Clinic (USA).

Given that our genes are difficult to change (I won't get into epigenetics), what are some avoidable dementia risk factors? Certain drugs may cause cognitive deterioration.

Today we look at four drugs that may cause cognitive decline.

Dementia and benzodiazepines

Benzodiazepine sedatives increase brain GABA levels. Example benzodiazepines:

  • Diazepam (Valium) (Valium)

  • Alprazolam (Xanax) (Xanax)

  • Clonazepam (Klonopin) (Klonopin)

Addiction and overdose are benzodiazepine risks. Yes! These medications don't raise dementia risk.

USC study: Benzodiazepines don't increase dementia risk in older adults.

Benzodiazepines can produce short- and long-term amnesia. This memory loss hinders memory formation. Extreme cases can permanently impair learning and memory. Anterograde amnesia is uncommon.

2. Statins and dementia

Statins reduce cholesterol. They prevent a cholesterol-making chemical. Examples:

  • Atorvastatin (Lipitor) (Lipitor)

  • Fluvastatin (Lescol XL) (Lescol XL)

  • Lovastatin (Altoprev) (Altoprev)

  • Pitavastatin (Livalo, Zypitamag) (Livalo, Zypitamag)

  • Pravastatin (Pravachol) (Pravachol)

  • Rosuvastatin (Crestor, Ezallor) (Crestor, Ezallor)

  • Simvastatin (Zocor) (Zocor)

Photo by Towfiqu barbhuiya on Unsplash

This finding is contentious. Harvard's Brigham and Womens Hospital's Dr. Joann Manson says:

“I think that the relationship between statins and cognitive function remains controversial. There’s still not a clear conclusion whether they help to prevent dementia or Alzheimer’s disease, have neutral effects, or increase risk.”

This one's off the dementia list.

3. Dementia and anticholinergic drugs

Anticholinergic drugs treat many conditions, including urine incontinence. Drugs inhibit acetylcholine (a brain chemical that helps send messages between cells). Acetylcholine blockers cause drowsiness, disorientation, and memory loss.

First-generation antihistamines, tricyclic antidepressants, and overactive bladder antimuscarinics are common anticholinergics among the elderly.

Anticholinergic drugs may cause dementia. One study found that taking anticholinergics for three years or more increased the risk of dementia by 1.54 times compared to three months or less. After stopping the medicine, the danger may continue.

4. Drugs for Parkinson's disease and dementia

Cleveland Clinic (USA) on Parkinson's:

Parkinson's disease causes age-related brain degeneration. It causes delayed movements, tremors, and balance issues. Some are inherited, but most are unknown. There are various treatment options, but no cure.

Parkinson's medications can cause memory loss, confusion, delusions, and obsessive behaviors. The drug's effects on dopamine cause these issues.

A 2019 JAMA Internal Medicine study found powerful anticholinergic medications enhance dementia risk.

Those who took anticholinergics had a 1.5 times higher chance of dementia. Individuals taking antidepressants, antipsychotic drugs, anti-Parkinson’s drugs, overactive bladder drugs, and anti-epileptic drugs had the greatest risk of dementia.

Anticholinergic medicines can lessen Parkinson's-related tremors, but they slow cognitive ability. Anticholinergics can cause disorientation and hallucinations in those over 70.

Photo by Wengang Zhai on Unsplash

5. Antiepileptic drugs and dementia

The risk of dementia from anti-seizure drugs varies with drugs. Levetiracetam (Keppra) improves Alzheimer's cognition.

One study linked different anti-seizure medications to dementia. Anti-epileptic medicines increased the risk of Alzheimer's disease by 1.15 times in the Finnish sample and 1.3 times in the German population. Depakote, Topamax are drugs.

Daniel Clery

3 years ago

Twisted device investigates fusion alternatives

German stellarator revamped to run longer, hotter, compete with tokamaks

Wendelstein 7-X’s complex geometry was a nightmare to build but, when fired up, worked from the start.

Tokamaks have dominated the search for fusion energy for decades. Just as ITER, the world's largest and most expensive tokamak, nears completion in southern France, a smaller, twistier testbed will start up in Germany.

If the 16-meter-wide stellarator can match or outperform similar-size tokamaks, fusion experts may rethink their future. Stellarators can keep their superhot gases stable enough to fuse nuclei and produce energy. They can theoretically run forever, but tokamaks must pause to reset their magnet coils.

The €1 billion German machine, Wendelstein 7-X (W7-X), is already getting "tokamak-like performance" in short runs, claims plasma physicist David Gates, preventing particles and heat from escaping the superhot gas. If W7-X can go long, "it will be ahead," he says. "Stellarators excel" Eindhoven University of Technology theorist Josefine Proll says, "Stellarators are back in the game." A few of startup companies, including one that Gates is leaving Princeton Plasma Physics Laboratory, are developing their own stellarators.

W7-X has been running at the Max Planck Institute for Plasma Physics (IPP) in Greifswald, Germany, since 2015, albeit only at low power and for brief runs. W7-X's developers took it down and replaced all inner walls and fittings with water-cooled equivalents, allowing for longer, hotter runs. The team reported at a W7-X board meeting last week that the revised plasma vessel has no leaks. It's expected to restart later this month to show if it can get plasma to fusion-igniting conditions.

Wendelstein 7-X’s twisting inner surface is now water cooled, enabling longer runs

Wendelstein 7-X's water-cooled inner surface allows for longer runs.

HOSAN/IPP

Both stellarators and tokamaks create magnetic gas cages hot enough to melt metal. Microwaves or particle beams heat. Extreme temperatures create a plasma, a seething mix of separated nuclei and electrons, and cause the nuclei to fuse, releasing energy. A fusion power plant would use deuterium and tritium, which react quickly. Non-energy-generating research machines like W7-X avoid tritium and use hydrogen or deuterium instead.

Tokamaks and stellarators use electromagnetic coils to create plasma-confining magnetic fields. A greater field near the hole causes plasma to drift to the reactor's wall.

Tokamaks control drift by circulating plasma around a ring. Streaming creates a magnetic field that twists and stabilizes ionized plasma. Stellarators employ magnetic coils to twist, not plasma. Once plasma physicists got powerful enough supercomputers, they could optimize stellarator magnets to improve plasma confinement.

W7-X is the first large, optimized stellarator with 50 6- ton superconducting coils. Its construction began in the mid-1990s and cost roughly twice the €550 million originally budgeted.

The wait hasn't disappointed researchers. W7-X director Thomas Klinger: "The machine operated immediately." "It's a friendly machine." It did everything we asked." Tokamaks are prone to "instabilities" (plasma bulging or wobbling) or strong "disruptions," sometimes associated to halted plasma flow. IPP theorist Sophia Henneberg believes stellarators don't employ plasma current, which "removes an entire branch" of instabilities.

In early stellarators, the magnetic field geometry drove slower particles to follow banana-shaped orbits until they collided with other particles and leaked energy. Gates believes W7-X's ability to suppress this effect implies its optimization works.

W7-X loses heat through different forms of turbulence, which push particles toward the wall. Theorists have only lately mastered simulating turbulence. W7-X's forthcoming campaign will test simulations and turbulence-fighting techniques.

A stellarator can run constantly, unlike a tokamak, which pulses. W7-X has run 100 seconds—long by tokamak standards—at low power. The device's uncooled microwave and particle heating systems only produced 11.5 megawatts. The update doubles heating power. High temperature, high plasma density, and extensive runs will test stellarators' fusion power potential. Klinger wants to heat ions to 50 million degrees Celsius for 100 seconds. That would make W7-X "a world-class machine," he argues. The team will push for 30 minutes. "We'll move step-by-step," he says.

W7-X's success has inspired VCs to finance entrepreneurs creating commercial stellarators. Startups must simplify magnet production.

Princeton Stellarators, created by Gates and colleagues this year, has $3 million to build a prototype reactor without W7-X's twisted magnet coils. Instead, it will use a mosaic of 1000 HTS square coils on the plasma vessel's outside. By adjusting each coil's magnetic field, operators can change the applied field's form. Gates: "It moves coil complexity to the control system." The company intends to construct a reactor that can fuse cheap, abundant deuterium to produce neutrons for radioisotopes. If successful, the company will build a reactor.

Renaissance Fusion, situated in Grenoble, France, raised €16 million and wants to coat plasma vessel segments in HTS. Using a laser, engineers will burn off superconductor tracks to carve magnet coils. They want to build a meter-long test segment in 2 years and a full prototype by 2027.

Type One Energy in Madison, Wisconsin, won DOE money to bend HTS cables for stellarator magnets. The business carved twisting grooves in metal with computer-controlled etching equipment to coil cables. David Anderson of the University of Wisconsin, Madison, claims advanced manufacturing technology enables the stellarator.

Anderson said W7-X's next phase will boost stellarator work. “Half-hour discharges are steady-state,” he says. “This is a big deal.”

Sara_Mednick

Sara_Mednick

3 years ago

Since I'm a scientist, I oppose biohacking

Understanding your own energy depletion and restoration is how to truly optimize

Photo: Towfiqu barbhuiya / Unsplash

Hack has meant many bad things for centuries. In the 1800s, a hack was a meager horse used to transport goods.

Modern usage describes a butcher or ax murderer's cleaver chop. The 1980s programming boom distinguished elegant code from "hacks". Both got you to your goal, but the latter made any programmer cringe and mutter about changing the code. From this emerged the hacker trope, the friendless anti-villain living in a murky hovel lit by the computer monitor, eating junk food and breaking into databases to highlight security system failures or steal hotdog money.

Remember the 1995 movie, Hackers, in which a bunch of super cool programmers (said no one ever) get caught up in a plot to destroy the world and only teenybopper Angelina Jolie and her punk rock gang of nerd-bots can use their lightening quick typing skills to save the world? Remember public phones?

Now, start-a-billion-dollar-business-from-your-garage types have shifted their sights from app development to DIY biology, coining the term "bio-hack". This is a required keyword and meta tag for every fitness-related podcast, book, conference, app, or device.

Bio-hacking involves bypassing your body and mind's security systems to achieve a goal. Many biohackers' initial goals were reasonable, like lowering blood pressure and weight. Encouraged by their own progress, self-determination, and seemingly exquisite control of their biology, they aimed to outsmart aging and death to live 180 to 1000 years (summarized well in this vox.com article).

With this grandiose north star, the hunt for novel supplements and genetic engineering began.

Companies selling do-it-yourself biological manipulations cite lab studies in mice as proof of their safety and success in reversing age-related diseases or promoting longevity in humans (the goal changes depending on whether a company is talking to the federal government or private donors).

The FDA is slower than science, they say. Why not alter your biochemistry by buying pills online, editing your DNA with a CRISPR kit, or using a sauna delivered to your home? How about a microchip or electrical stimulator?

What could go wrong?


I'm not the neo-police, making citizen's arrests every time someone introduces a new plumbing gadget or extrapolates from animal research on resveratrol or catechins that we should drink more red wine or eat more chocolate. As a scientist who's spent her career asking, "Can we get better?" I've come to view bio-hacking as misguided, profit-driven, and counterproductive to its followers' goals.

We're creatures of nature. Despite all the new gadgets and bio-hacks, we still use Roman plumbing technology, and the best way to stay fit, sharp, and happy is to follow a recipe passed down since the beginning of time. Bacteria, plants, and all natural beings are rhythmic, with alternating periods of high activity and dormancy, whether measured in seconds, hours, days, or seasons. Nature repeats successful patterns.

During the Upstate, every cell in your body is naturally primed and pumped full of glycogen and ATP (your cells' energy currencies), as well as cortisol, which supports your muscles, heart, metabolism, cognitive prowess, emotional regulation, and general "get 'er done" attitude. This big energy release depletes your batteries and requires the Downstate, when your subsystems recharge at the cellular level.

Downstates are when you give your heart a break from pumping nutrient-rich blood through your body; when you give your metabolism a break from inflammation, oxidative stress, and sympathetic arousal caused by eating fast food — or just eating too fast; or when you give your mind a chance to wander, think bigger thoughts, and come up with new creative solutions. When you're responding to notifications, emails, and fires, you can't relax.

Every biological plant and animal is regulated by rhythms of energy-depleting Upstate and energy-restoring Downstates.

Downstates aren't just for consistently recharging your battery. By spending time in the Downstate, your body and brain get extra energy and nutrients, allowing you to grow smarter, faster, stronger, and more self-regulated. This state supports half-marathon training, exam prep, and mediation. As we age, spending more time in the Downstate is key to mental and physical health, well-being, and longevity.

When you prioritize energy-demanding activities during Upstate periods and energy-replenishing activities during Downstate periods, all your subsystems, including cardiovascular, metabolic, muscular, cognitive, and emotional, hum along at their optimal settings. When you synchronize the Upstates and Downstates of these individual rhythms, their functioning improves. A hard workout causes autonomic stress, which triggers Downstate recovery.

This zig-zag trajectory of performance improvement illustrates that getting better at anything in life isn’t a straight shot. The close-up box shows how prioritizing Downstate recovery after an Upstate exertion (e.g., hard workout) leads to RECOVERYPLUS. Image from The Power of the Downstate by Sara C. Mednick PhD.

By choosing the right timing and type of exercise during the day, you can ensure a deeper recovery and greater readiness for the next workout by working with your natural rhythms and strengthening your autonomic and sleep Downstates.

Morning cardio workouts increase deep sleep compared to afternoon workouts. Timing and type of meals determine when your sleep hormone melatonin is released, ushering in sleep.

Rhythm isn't a hack. It's not a way to cheat the system or the boss. Nature has honed its optimization wisdom over trillions of days and nights. Stop looking for quick fixes. You're a whole system made of smaller subsystems that must work together to function well. No one pill or subsystem will make it all work. Understanding and coordinating your rhythms is free, easy, and only benefits you.

Dr. Sara C. Mednick is a cognitive neuroscientist at UC Irvine and author of The Power of the Downstate (HachetteGO)

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ʟ ᴜ ᴄ ʏ

ʟ ᴜ ᴄ ʏ

3 years ago

The Untapped Gold Mine of Inspiration and Startup Ideas

I joined the 1000 Digital Startups Movement (Gerakan 1000 Startup Digital) in 2017 and learned a lot about the startup sector. My previous essay outlined what a startup is and what must be prepared. Here I'll offer raw ideas for better products.

Image by macrovector on Freepik

Intro

A good startup solves a problem. These can include environmental, economic, energy, transportation, logistics, maritime, forestry, livestock, education, tourism, legal, arts and culture, communication, and information challenges. Everything I wrote is simply a basic idea (as inspiration) and requires more mapping and validation. Learn how to construct a startup to maximize launch success.

Adrian Gunadi (Investree Co-Founder) taught me that a Founder or Co-Founder must be willing to be CEO (Chief Everything Officer). Everything is independent, including drafting a proposal, managing finances, and scheduling appointments. The best individuals will come to you if you're the best. It's easier than consulting Andy Zain (Kejora Capital Founder).

Description

To help better understanding from your idea, try to answer this following questions:

- Describe your idea/application
Maximum 1000 characters.

- Background
Explain the reasons that prompted you to realize the idea/application.

- Objective
Explain the expected goals of the creation of the idea/application.

- Solution
A solution that tells your idea can be the right solution for the problem at hand.

- Uniqueness
What makes your idea/app unique?

- Market share
Who are the people who need and are looking for your idea?

- Marketing Ways and Business Models
What is the best way to sell your idea and what is the business model?

Not everything here is a startup idea. It's meant to inspire creativity and new perspectives.

Ideas

#Application

1. Medical students can operate on patients or not. Applications that train prospective doctors to distinguish body organs and their placement are useful. In the advanced stage, the app can be built with numerous approaches so future doctors can practice operating on patients based on their ailments. If they made a mistake, they'd start over. Future doctors will be more assured and make fewer mistakes this way.

2. VR (virtual reality) technology lets people see 3D space from afar. Later, similar technology was utilized to digitally sell properties, so buyers could see the inside and room contents. Every gadget has flaws. It's like a gold mine for robbers. VR can let prospective students see a campus's facilities. This facility can also help hotels promote their products.

3. How can retail entrepreneurs maximize sales? Most popular goods' sales data. By using product and brand/type sales figures, entrepreneurs can avoid overstocking. Walmart computerized their procedures to track products from the manufacturer to the store. As Retail Link products sell out, suppliers can immediately step in.

4. Failing to marry is something to be avoided. But if it had to happen, the loss would be like the proverb “rub salt into the wound”.  On the I do Now I dont website, Americans who don't marry can resell their jewelry to other brides-to-be. If some want to cancel the wedding and receive their down money and dress back, others want a wedding with particular criteria, such as a quick date and the expected building. Create a DP takeover marketplace for both sides.

#Games

1. Like in the movie, players must exit the maze they enter within 3 minutes or the shape will change, requiring them to change their strategy. The maze's transformation time will shorten after a few stages.

2. Treasure hunts involve following clues to uncover hidden goods. Here, numerous sponsors are combined in one boat, and participants can choose a game based on the prizes. Let's say X-mart is a sponsor and provides riddles or puzzles to uncover the prize in their store. After gathering enough points, the player can trade them for a gift utilizing GPS and AR (augmented reality). Players can collaborate to increase their chances of success.

3. Where's Wally? Where’s Wally displays a thick image with several things and various Wally-like characters. We must find the actual Wally, his companions, and the desired object. Make a game with a map where players must find objects for the next level. The player must find 5 artifacts randomly placed in an Egyptian-style mansion, for example. In the room, there are standard tickets, pass tickets, and gold tickets that can be removed for safekeeping, as well as a wall-mounted carpet that can be stored but not searched and turns out to be a flying rug that can be used to cross/jump to a different place. Regular tickets are spread out since they can buy life or stuff. At a higher level, a black ticket can lower your ordinary ticket. Objects can explode, scattering previously acquired stuff. If a player runs out of time, they can exchange a ticket for more.

#TVprogram

1. At the airport there are various visitors who come with different purposes. Asking tourists to live for 1 or 2 days in the city will be intriguing to witness.

2. Many professions exist. Carpenters, cooks, and lawyers must have known about job desks. Does HRD (Human Resource Development) only recruit new employees? Many don't know how to become a CEO, CMO, COO, CFO, or CTO. Showing young people what a Program Officer in an NGO does can help them choose a career.

#StampsCreations

Philatelists know that only the government can issue stamps. I hope stamps are creative so they have more worth.

1. Thermochromic pigments (leuco dyes) are well-known for their distinctive properties. By putting pigments to black and white batik stamps, for example, the black color will be translucent and display the basic color when touched (at a hot temperature).

2. In 2012, Liechtenstein Post published a laser-art Chinese zodiac stamp. Belgium (Bruges Market Square 2012), Taiwan (Swallow Tail Butterfly 2009), etc. Why not make a stencil of the president or king/queen?

3. Each country needs its unique identity, like Taiwan's silk and bamboo stamps. Create from your country's history. Using traditional paper like washi (Japan), hanji (Korea), and daluang/saeh (Indonesia) can introduce a country's culture.

4. Garbage has long been a problem. Bagasse, banana fronds, or corn husks can be used as stamp material.

5. Austria Post published a stamp containing meteor dust in 2006. 2004 meteorite found in Morocco produced the dust. Gibraltar's Rock of Gilbraltar appeared on stamps in 2002. What's so great about your country? East Java is muddy (Lapindo mud). Lapindo mud stamps will be popular. Red sand at Pink Beach, East Nusa Tenggara, could replace the mud.

#PostcardCreations

1. Map postcards are popular because they make searching easier. Combining laser-cut road map patterns with perforated 200-gram paper glued on 400-gram paper as a writing medium. Vision-impaired people can use laser-cut maps.

2. Regional art can be promoted by tucking traditional textiles into postcards.

3. A thin canvas or plain paper on the card's front allows the giver to be creative.

4. What is local crop residue? Cork lids, maize husks, and rice husks can be recycled into postcard materials.

5. Have you seen a dried-flower bookmark? Cover the postcard with mica and add dried flowers. If you're worried about losing the flowers, you can glue them or make a postcard envelope.

6. Wood may be ubiquitous; try a 0.2-mm copper plate engraved with an image and connected to a postcard as a writing medium.

7. Utilized paper pulp can be used to hold eggs, smartphones, and food. Form a smooth paper pulp on the plate with the desired image, the Golden Gate bridge, and paste it on your card.

8. Postcards can promote perfume. When customers rub their hands on the card with the perfume image, they'll smell the aroma.

#Tour #Travel

Tourism activities can be tailored to tourists' interests or needs. Each tourist benefits from tourism's distinct aim.

Let's define tourism's objective and purpose.

  • Holiday Tour is a tour that its participants plan and do in order to relax, have fun, and amuse themselves.

  • A familiarization tour is a journey designed to help travelers learn more about (survey) locales connected to their line of work.

  • An educational tour is one that aims to give visitors knowledge of the field of work they are visiting or an overview of it.

  • A scientific field is investigated and knowledge gained as the major goal of a scientific tour.

  • A pilgrimage tour is one designed to engage in acts of worship.

  • A special mission tour is one that has a specific goal, such a commerce mission or an artistic endeavor.

  • A hunting tour is a destination for tourists that plans organized animal hunting that is only allowed by local authorities for entertainment purposes.

Every part of life has tourism potential. Activities include:

1. Those who desire to volunteer can benefit from the humanitarian theme and collaboration with NGOs. This activity's profit isn't huge but consider the environmental impact.

2. Want to escape the city? Meditation travel can help. Beautiful spots around the globe can help people forget their concerns. A certified yoga/meditation teacher can help travelers release bad energy.

3. Any prison visitors? Some prisons, like those for minors under 17, are open to visitors. This type of tourism helps mental convicts reach a brighter future.

4. Who has taken a factory tour/study tour? Outside-of-school study tour (for ordinary people who have finished their studies). Not everyone in school could tour industries, workplaces, or embassies to learn and be inspired. Shoyeido (an incense maker) and Royce (a chocolate maker) offer factory tours in Japan.

5. Develop educational tourism like astronomy and archaeology. Until now, only a few astronomy enthusiasts have promoted astronomy tourism. In Indonesia, archaeology activities focus on site preservation, and to participate, office staff must undertake a series of training (not everyone can take a sabbatical from their routine). Archaeological tourist activities are limited, whether held by history and culture enthusiasts or in regional tours.

6. Have you ever longed to observe a film being made or your favorite musician rehearsing? Such tours can motivate young people to pursue entertainment careers.

7. Pamper your pets to reduce stress. Many pet owners don't have time for walks or treats. These premium services target the wealthy.

8. A quirky idea to provide tours for imaginary couples or things. Some people marry inanimate objects or animals and seek to make their lover happy; others cherish their ashes after death.

#MISCideas

1. Fashion is a lifestyle, thus people often seek fresh materials. Chicken claws, geckos, snake skin casings, mice, bats, and fish skins are also used. Needs some improvement, definitely.

2. As fuel supplies become scarcer, people hunt for other energy sources. Sound is an underutilized renewable energy. The Batechsant technology converts environmental noise into electrical energy, according to study (Battery Technology Of Sound Power Plant). South Korean researchers use Sound-Driven Piezoelectric Nanowire based on Nanogenerators to recharge cell phone batteries. The Batechsant system uses existing noise levels to provide electricity for street lamp lights, aviation, and ships. Using waterfall sound can also energize hard-to-reach locations.

3. A New York Times reporter said IQ doesn't ensure success. Our school system prioritizes IQ above EQ (Emotional Quotient). EQ is a sort of human intelligence that allows a person to perceive and analyze the dynamics of his emotions when interacting with others (and with himself). EQ is suspected of being a bigger source of success than IQ. EQ training can gain greater attention to help people succeed. Prioritize role models from school stakeholders, teachers, and parents to improve children' EQ.

4. Teaching focuses more on theory than practice, so students are less eager to explore and easily forget if they don't pay attention. Has an engineer ever made bricks from arid red soil? Morocco's non-college-educated builders can create weatherproof bricks from red soil without equipment. Can mechanical engineering grads create a water pump to solve water shortages in remote areas? Art graduates can innovate beyond only painting. Artists may create kinetic sculpture by experimenting so much. Young people should understand these sciences so they can be more creative with their potential. These might be extracurricular activities in high school and university.

5. People have been trying to recycle agricultural waste for a long time. Mycelium helps replace light, easily crushed tiles and bricks (a collection of hyphae like in the manufacture of tempe). Waste must contain lignocellulose. In this vein, anti-mainstream painting canvases can be made. The goal is to create the canvas uneven like an amoeba outline, not square or spherical. The resulting canvas is lightweight and needs no frame. Then what? Open source your idea like Precious Plastic to establish a community. By propagating this notion, many knowledgeable people will help improve your product's quality and impact.

6. As technology and humans adapt, fraud increases. Making phony doctor's letters to fool superiors, fake credentials to get hired, fraudulent land certificates to make money, and fake news (hoax). The existence of a Wikimedia can aid the community by comparing bogus and original information.

7. Do you often hit a problem-solving impasse? Since the Doraemon bag hasn't been made, construct an Idea Bank. Everyone can contribute to solving problems here. How do you recruit volunteers? Obviously, a reward is needed. Contributors can become moderators or gain complimentary tickets to TIA (Tech in Asia) conferences. Idea Bank-related concepts: the rise of startups without a solid foundation generates an age as old as corn that does not continue. Those with startup ideas should describe them here so they can be validated by other users. Other users can contribute input if a comparable notion is produced to improve the product or integrate it. Similar-minded users can become Co-Founders.

8. Why not invest in fruit/vegetables, inspired by digital farming? The landowner obtains free fruit without spending much money on maintenance. Investors can get fruits/vegetables in larger quantities, fresher, and cheaper during harvest. Fruits and vegetables are often harmed if delivered too slowly. Rich investors with limited land can invest in teak, agarwood, and other trees. When harvesting, investors might choose raw results or direct wood sales earnings. Teak takes at least 7 years to harvest, therefore long-term wood investments carry the risk of crop failure.

9. Teenagers in distant locations can't count, read, or write. Many factors hinder locals' success. Life's demands force them to work instead of study. Creating a learning playground may attract young people to learning. Make a skatepark at school. Skateboarders must learn in school. Donations buy skateboards.

10. Globally, online taxi-bike is known. By hiring a motorcycle/car online, people no longer bother traveling without a vehicle. What if you wish to cross the island or visit remote areas? Is online boat or helicopter rental possible like online taxi-bike? Such a renting process has been done independently thus far and cannot be done quickly.

11. What do startups need now? A startup or investor consultant. How many startups fail to become Unicorns? Many founders don't know how to manage investor money, therefore they waste it on promotions and other things. Many investors only know how to invest and can't guide a struggling firm.

“In times of crisis, the wise build bridges, while the foolish build barriers.” — T’Challa [Black Panther]

Don't chase cash. Money is a byproduct. Profit-seeking is stressful. Market requirements are opportunities. If you have something to say, please comment.

This is only informational. Before implementing ideas, do further study.

Thomas Huault

Thomas Huault

3 years ago

A Mean Reversion Trading Indicator Inspired by Classical Mechanics Is The Kinetic Detrender

DATA MINING WITH SUPERALGORES

Old pots produce the best soup.

Photo by engin akyurt on Unsplash

Science has always inspired indicator design. From physics to signal processing, many indicators use concepts from mechanical engineering, electronics, and probability. In Superalgos' Data Mining section, we've explored using thermodynamics and information theory to construct indicators and using statistical and probabilistic techniques like reduced normal law to take advantage of low probability events.

An asset's price is like a mechanical object revolving around its moving average. Using this approach, we could design an indicator using the oscillator's Total Energy. An oscillator's energy is finite and constant. Since we don't expect the price to follow the harmonic oscillator, this energy should deviate from the perfect situation, and the maximum of divergence may provide us valuable information on the price's moving average.

Definition of the Harmonic Oscillator in Few Words

Sinusoidal function describes a harmonic oscillator. The time-constant energy equation for a harmonic oscillator is:

With

Time saves energy.

In a mechanical harmonic oscillator, total energy equals kinetic energy plus potential energy. The formula for energy is the same for every kind of harmonic oscillator; only the terms of total energy must be adapted to fit the relevant units. Each oscillator has a velocity component (kinetic energy) and a position to equilibrium component (potential energy).

The Price Oscillator and the Energy Formula

Considering the harmonic oscillator definition, we must specify kinetic and potential components for our price oscillator. We define oscillator velocity as the rate of change and equilibrium position as the price's distance from its moving average.

Price kinetic energy:

It's like:

With

and

L is the number of periods for the rate of change calculation and P for the close price EMA calculation.

Total price oscillator energy =

Given that an asset's price can theoretically vary at a limitless speed and be endlessly far from its moving average, we don't expect this formula's outcome to be constrained. We'll normalize it using Z-Score for convenience of usage and readability, which also allows probabilistic interpretation.

Over 20 periods, we'll calculate E's moving average and standard deviation.

We calculated Z on BTC/USDT with L = 10 and P = 21 using Knime Analytics.

The graph is detrended. We added two horizontal lines at +/- 1.6 to construct a 94.5% probability zone based on reduced normal law tables. Price cycles to its moving average oscillate clearly. Red and green arrows illustrate where the oscillator crosses the top and lower limits, corresponding to the maximum/minimum price oscillation. Since the results seem noisy, we may apply a non-lagging low-pass or multipole filter like Butterworth or Laguerre filters and employ dynamic bands at a multiple of Z's standard deviation instead of fixed levels.

Kinetic Detrender Implementation in Superalgos

The Superalgos Kinetic detrender features fixed upper and lower levels and dynamic volatility bands.

The code is pretty basic and does not require a huge amount of code lines.

It starts with the standard definitions of the candle pointer and the constant declaration :

let candle = record.current
let len = 10
let P = 21
let T = 20
let up = 1.6
let low = 1.6

Upper and lower dynamic volatility band constants are up and low.

We proceed to the initialization of the previous value for EMA :

if (variable.prevEMA === undefined) {
    variable.prevEMA = candle.close
}

And the calculation of EMA with a function (it is worth noticing the function is declared at the end of the code snippet in Superalgos) :

variable.ema = calculateEMA(P, candle.close, variable.prevEMA)
//EMA calculation
function calculateEMA(periods, price, previousEMA) {
    let k = 2 / (periods + 1)
    return price * k + previousEMA * (1 - k)
}

The rate of change is calculated by first storing the right amount of close price values and proceeding to the calculation by dividing the current close price by the first member of the close price array:

variable.allClose.push(candle.close)
if (variable.allClose.length > len) {
    variable.allClose.splice(0, 1)
}
if (variable.allClose.length === len) {
    variable.roc = candle.close / variable.allClose[0]
} else {
    variable.roc = 1
}

Finally, we get energy with a single line:

variable.E = 1 / 2 * len * variable.roc + 1 / 2 * P * candle.close / variable.ema

The Z calculation reuses code from Z-Normalization-based indicators:

variable.allE.push(variable.E)
if (variable.allE.length > T) {
    variable.allE.splice(0, 1)
}
variable.sum = 0
variable.SQ = 0
if (variable.allE.length === T) {
    for (var i = 0; i < T; i++) {
        variable.sum += variable.allE[i]
    }
    variable.MA = variable.sum / T
for (var i = 0; i < T; i++) {
        variable.SQ += Math.pow(variable.allE[i] - variable.MA, 2)
    }
    variable.sigma = Math.sqrt(variable.SQ / T)
variable.Z = (variable.E - variable.MA) / variable.sigma
} else {
    variable.Z = 0
}
variable.allZ.push(variable.Z)
if (variable.allZ.length > T) {
    variable.allZ.splice(0, 1)
}
variable.sum = 0
variable.SQ = 0
if (variable.allZ.length === T) {
    for (var i = 0; i < T; i++) {
        variable.sum += variable.allZ[i]
    }
    variable.MAZ = variable.sum / T
for (var i = 0; i < T; i++) {
        variable.SQ += Math.pow(variable.allZ[i] - variable.MAZ, 2)
    }
    variable.sigZ = Math.sqrt(variable.SQ / T)
} else {
    variable.MAZ = variable.Z
    variable.sigZ = variable.MAZ * 0.02
}
variable.upper = variable.MAZ + up * variable.sigZ
variable.lower = variable.MAZ - low * variable.sigZ

We also update the EMA value.

variable.prevEMA = variable.EMA
BTD/USDT candle chart at 01-hs timeframe with the Kinetic detrender and its 2 red fixed level and black dynamic levels

Conclusion

We showed how to build a detrended oscillator using simple harmonic oscillator theory. Kinetic detrender's main line oscillates between 2 fixed levels framing 95% of the values and 2 dynamic levels, leading to auto-adaptive mean reversion zones.

Superalgos' Normalized Momentum data mine has the Kinetic detrender indication.

All the material here can be reused and integrated freely by linking to this article and Superalgos.

This post is informative and not financial advice. Seek expert counsel before trading. Risk using this material.

Jayden Levitt

Jayden Levitt

3 years ago

Billionaire who was disgraced lost his wealth more quickly than anyone in history

If you're not genuine, you'll be revealed.

Photo By Fl Institute — Flikr

Sam Bankman-Fried (SBF) was called the Cryptocurrency Warren Buffet.

No wonder.

SBF's trading expertise, Blockchain knowledge, and ability to construct FTX attracted mainstream investors.

He had a fantastic worldview, donating much of his riches to charity.

As the onion layers peel back, it's clear he wasn't the altruistic media figure he portrayed.

SBF's mistakes were disastrous.

  • Customer deposits were traded and borrowed by him.

  • With ten other employees, he shared a $40 million mansion where they all had polyamorous relationships.

  • Tone-deaf and wasteful marketing expenditures, such as the $200 million spent to change the name of the Miami Heat stadium to the FTX Arena

  • Democrats received a $40 million campaign gift.

  • And now there seems to be no regret.

FTX was a 32-billion-dollar cryptocurrency exchange.

It went bankrupt practically overnight.

SBF, FTX's creator, exploited client funds to leverage trade.

FTX had $1 billion in customer withdrawal reserves against $9 billion in liabilities in sister business Alameda Research.

Bloomberg Billionaire Index says it's the largest and fastest net worth loss in history.

It gets worse.

SBF's net worth is $900 Million, however he must still finalize FTX's bankruptcy.

SBF's arrest in the Bahamas and SEC inquiry followed news that his cryptocurrency exchange had crashed, losing billions in customer deposits.

A journalist contacted him on Twitter D.M., and their exchange is telling.

His ideas are revealed.

Kelsey Piper says they didn't expect him to answer because people under investigation don't comment.

Bankman-Fried wanted to communicate, and the interaction shows he has little remorse.

SBF talks honestly about FTX gaming customers' money and insults his competition.

Reporter Kelsey Piper was outraged by what he said and felt the mistakes SBF says plague him didn't evident in the messages.

Before FTX's crash, SBF was a poster child for Cryptocurrency regulation and avoided criticizing U.S. regulators.

He tells Piper that his lobbying is just excellent PR.

It shows his genuine views and supports cynics' opinions that his attempts to win over U.S. authorities were good for his image rather than Crypto.

SBF’s responses are in Grey, and Pipers are in Blue.

Source — Kelsey Piper

It's unclear if SBF cut corners for his gain. In their Twitter exchange, Piper revisits an interview question about ethics.

SBF says, "All the foolish sh*t I said"

SBF claims FTX has never invested customer monies.

Source — Kelsey PiperSource — Kelsey Piper

Piper challenged him on Twitter.

While he insisted FTX didn't use customer deposits, he said sibling business Alameda borrowed too much from FTX's balance sheet.

He did, basically.

When consumers tried to withdraw money, FTX was short.

SBF thought Alameda had enough money to cover FTX customers' withdrawals, but life sneaks up on you.

Source — Kelsey Piper

SBF believes most exchanges have done something similar to FTX, but they haven't had a bank run (a bunch of people all wanting to get their deposits out at the same time).

SBF believes he shouldn't have consented to the bankruptcy and kept attempting to raise more money because withdrawals would be open in a month with clients whole.

If additional money came in, he needed $8 billion to bridge the creditors' deficit, and there aren't many corporations with $8 billion to spare.

Once clients feel protected, they will continue to leave their assets on the exchange, according to one idea.

Kevin OLeary, a world-renowned hedge fund manager, says not all investors will walk through the open gate once the company is safe, therefore the $8 Billion wasn't needed immediately.

SBF claims the bankruptcy was his biggest error because he could have accumulated more capital.

Source — Kelsey PiperSource — Kelsey Piper

Final Reflections

Sam Bankman-Fried, 30, became the world's youngest billionaire in four years.

Never listen to what people say about investing; watch what they do.

SBF is a trader who gets wrecked occasionally.

Ten first-time entrepreneurs ran FTX, screwing each other with no risk management.

It prevents opposing or challenging perspectives and echo chamber highs.

Twitter D.M. conversation with a journalist is the final nail.

He lacks an experienced crew.

This event will surely speed up much-needed regulation.

It's also prompted cryptocurrency exchanges to offer proof of reserves to calm customers.