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The woman

The woman

3 years ago

I received a $2k bribe to replace another developer in an interview

More on Productivity

Ethan Siegel

Ethan Siegel

2 years ago

How you view the year will change after using this one-page calendar.

The conventional way we display annual calendars, at left, requires us to examine each month separately, either relegating the full year to a tiny font on a single page or onto 12 separate pages. Instead, the one-page calendar, at right, enables you to find whatever you want all throughout the year. (Credit: E. Siegel, with a public domain conventional calendar at left)

No other calendar is simpler, smaller, and reusable year after year. It works and is used here.

Most of us discard and replace our calendars annually. Each month, we move our calendar ahead another page, thus if we need to know which day of the week corresponds to a given day/month combination, we have to calculate it or flip forward/backward to the corresponding month. Questions like:

  • What day does this year's American Thanksgiving fall on?

  • Which months contain a Friday the thirteenth?

  • When is July 4th? What day of the week?

  • Alternatively, what day of the week is Christmas?

They're hard to figure out until you switch to the right month or look up all the months.

However, mathematically, the answers to these questions or any question that requires matching the day of the week with the day/month combination in a year are predictable, basic, and easy to work out. If you use this one-page calendar instead of a 12-month calendar, it lasts the whole year and is easy to alter for future years. Let me explain.

Rather than a calendar displaying separate images for each month out of the year, this one-page calendar can be used to match up the day of the week with the dates/months of the year with perfect accuracy all in a single view. (Credit: E. Siegel)

The 2023 one-page calendar is above. The days of the month are on the lower left, which works for all months if you know that:

  • There are 31 days in January, March, May, July, August, October, and December.

  • All of the months of April, June, September, and November have 30 days.

  • And depending on the year, February has either 28 days (in non-leap years) or 29 days (in leap years).

If you know this, this calendar makes it easy to match the day/month of the year to the weekday.

Here are some instances. American Thanksgiving is always on the fourth Thursday of November. You'll always know the month and day of the week, but the date—the day in November—changes each year.

On any other calendar, you'd have to flip to November to see when the fourth Thursday is. This one-page calendar only requires:

  • pick the month of November in the top-right corner to begin.

  • drag your finger down until Thursday appears,

  • then turn left and follow the monthly calendar until you reach the fourth Thursday.

To find American Thanksgiving, you need to find the 4th Thursday in November. Using the one-page calendar, start at November, move down to find Thursday, then move to the left to count off to the fourth Thursday in November. In 2023, that date will be November 23rd. (Credit: E. Siegel)

It's obvious: 2023 is the 23rd American Thanksgiving. For every month and day-of-the-week combination, start at the month, drag your finger down to the desired day, and then move to the left to see which dates match.

What if you knew the day of the week and the date of the month, but not the month(s)?

A different method using the same one-page calendar gives the answer. Which months have Friday the 13th this year? Just:

  • begin on the 13th of the month, the day you know you desire,

  • then swipe right with your finger till Friday appears.

  • and then work your way up until you can determine which months the specific Friday the 13th falls under.

If you know which date/day-of-the-week combination you’re seeking but don’t know which months will meet that criteria, start with the date (1–31), move to the right until you find the day of the week you want, then move up and find which months match that criteria. Every year will always have at least one such combination. (Credit: E. Siegel)

One Friday the 13th occurred in January 2023, and another will occur in October.

The most typical reason to consult a calendar is when you know the month/day combination but not the day of the week.

Compared to single-month calendars, the one-page calendar excels here. Take July 4th, for instance. Find the weekday here:

  • beginning on the left on the fourth of the month, as you are aware,

  • also begin with July, the month of the year you are most familiar with, at the upper right,

  • you should move your two fingers in the opposite directions till they meet: on a Tuesday in 2023.

That's how you find your selected day/month combination's weekday.

If you were curious as to which day of the week July 4th, 2023 fell on, rather than flipping a conventional calendar to July and seeing, you could trace “4” to the right and “July” down, finding where they meet (on a Tuesday) revealing the day-of-the-week. (Credit: E. Siegel)

Another example: Christmas. Christmas Day is always December 25th, however unless your conventional calendar is open to December of your particular year, a question like "what day of the week is Christmas?" difficult to answer.

Unlike the one-page calendar!

Remember the left-hand day of the month. Top-right, you see the month. Put two fingers, one from each hand, on the date (25th) and the month (December). Slide the day hand to the right and the month hand downwards until they touch.

They meet on Monday—December 25, 2023.

Using the one-page calendar for 2023, you can figure out the day-of-the-week of any calendar day by placing one finger on the “date” at left and another on the “month” at top. By moving your fingers respectively to the right and down, where they meet will reveal the day of the week to you. (Credit: E. Siegel)

For 2023, that's fine, but what happens in 2024? Even worse, what if we want to know the day-of-the-week/day/month combo many years from now?

I think the one-page calendar shines here.

Except for the blue months in the upper-right corner of the one-page calendar, everything is the same year after year. The months also change in a consistent fashion.

Each non-leap year has 365 days—one more than a full 52 weeks (which is 364). Since January 1, 2023 began on a Sunday and 2023 has 365 days, we immediately know that December 31, 2023 will conclude on a Sunday (which you can confirm using the one-page calendar) and that January 1, 2024 will begin on a Monday. Then, reorder the months for 2024, taking in mind that February will have 29 days in a leap year.

This image shows the one-page calendar view for the next leap year we’re going to experience: 2024. Note that the monthly patterns have changed from how they were in a non-leap year, displaying a new pattern unique to leap years, corresponding to the fact that February has 29 days instead of 28. (Credit: E. Siegel)

Please note the differences between 2023 and 2024 month placement. In 2023:

  • October and January began on the same day of the week.

  • On the following Monday of the week, May began.

  • August started on the next day,

  • then the next weekday marked the start of February, March, and November, respectively.

  • Unlike June, which starts the following weekday,

  • While September and December start on the following day of the week,

  • Lastly, April and July start one extra day later.

Since 2024 is a leap year, February has 29 days, disrupting the rhythm. Month placements change to:

  • The first day of the week in January, April, and July is the same.

  • October will begin the following day.

  • Possibly starting the next weekday,

  • February and August start on the next weekday,

  • beginning on the following day of the week between March and November,

  • beginning the following weekday in June,

  • and commencing one more day of the week after that, September and December.

Due to the 366-day leap year, 2025 will start two days later than 2024 on January 1st.

The non-leap year 2025 has the same calendar as 2023, expect with the days-of-the-week that each month begins on shifted forward by three days for each month. This is because 2023 was not a leap year and 2024 was, meaning that an extra 3 days are needed over and above the 104 full weeks contained in 2023 and 2024 combined. (Credit: E. Siegel)

Now, looking at the 2025 calendar, you can see that the 2023 pattern of which months start on which days is repeated! The sole variation is a shift of three days-of-the-week ahead because 2023 had one more day (365) than 52 full weeks (364), and 2024 had two more days (366). Again,

  • On Wednesday this time, January and October begin on the same day of the week.

  • Although May begins on Thursday,

  • August begins this Friday.

  • March, November, and February all begin on a Saturday.

  • Beginning on a Sunday in June

  • Beginning on Monday are September and December,

  • and on Tuesday, April and July begin.

In 2026 and 2027, the year will commence on a Thursday and a Friday, respectively.

The one-page calendars for 2026 and 2027, as shown next to one another. Note that the calendars are identical, save that the day-of-the-week that each month begins on is shifted by one day from the prior year to the next. This occurs every time a non-leap year is followed by another non-leap year. (Credit: E. Siegel)

We must return to our leap year monthly arrangement in 2028. Yes, January 1, 2028 begins on a Saturday, but February, which begins on a Tuesday three days before January, will have 29 days. Thus:

  • Start dates for January, April, and July are all Saturdays.

  • Given that October began on Sunday,

  • Although May starts on a Monday,

  • beginning on a Tuesday in February and August,

  • Beginning on a Wednesday in March and November,

  • Beginning on Thursday, June

  • and Friday marks the start of September and December.

This is great because there are only 14 calendar configurations: one for each of the seven non-leap years where January 1st begins on each of the seven days of the week, and one for each of the seven leap years where it begins on each day of the week.

This example of a one-page calendar, which represents the year 2028, will be valid for all leap years that begin with January 1st on a Saturday. The leap year version of the one-page calendar repeats every 28 years, unless you pass a non-leap year ending in “00,” in which case the repeat will either be 12 or 40 years instead. (Credit: E. Siegel)

The 2023 calendar will function in 2034, 2045, 2051, 2062, 2073, 2079, 2090, 2102, 2113, and 2119. Except when passing over a non-leap year that ends in 00, like 2100, the repeat time always extends to 12 years or shortens to an extra 6 years.

  • The pattern is repeated in 2025's calendar in 2031, 2042, 2053, 2059, 2070, 2081, 2087, 2098, 2110, and 2121.

  • The extra 6-year repeat at the end of the century on the calendar for 2026 will occur in the years 2037, 2043, 2054, 2065, 2071, 2082, 2093, 2099, 2105, and 2122.

  • The 2027s calendar repeats in 2038, 2049, 2055, 2066, 2077, 2083, 2094, 2100, 2106, and 2117, almost exactly matching the 2026s pattern.

For leap years, the recurrence pattern is every 28 years when not passing a non-leap year ending in 00, or 12 or 40 years when we do. 2024's calendar repeats in 2052, 2080, 2120, 2148, 2176, and 2216; 2028's in 2056, 2084, 2124, 2152, 2180, and 2220.

Knowing January 1st and whether it's a leap year lets you construct a one-page calendar for any year. Try it—you might find it easier than any other alternative!

Jari Roomer

Jari Roomer

2 years ago

Three Simple Daily Practices That Will Immediately Double Your Output

Most productive people are habitual.

Photo by Headway on Unsplash

Early in the day, do important tasks.

In his best-selling book Eat That Frog, Brian Tracy advised starting the day with your hardest, most important activity.

Most individuals work best in the morning. Energy and willpower peak then.

Mornings are also ideal for memory, focus, and problem-solving.

Thus, the morning is ideal for your hardest chores.

It makes sense to do these things during your peak performance hours.

Additionally, your morning sets the tone for the day. According to Brian Tracy, the first hour of the workday steers the remainder.

After doing your most critical chores, you may feel accomplished, confident, and motivated for the remainder of the day, which boosts productivity.

Develop Your Essentialism

In Essentialism, Greg McKeown claims that trying to be everything to everyone leads to mediocrity and tiredness.

You'll either burn out, be spread too thin, or compromise your ideals.

Greg McKeown advises Essentialism:

Clarify what’s truly important in your life and eliminate the rest.

Eliminating non-essential duties, activities, and commitments frees up time and energy for what matters most.

According to Greg McKeown, Essentialists live by design, not default.

You'll be happier and more productive if you follow your essentials.

Follow these three steps to live more essentialist.

Prioritize Your Tasks First

What matters most clarifies what matters less. List your most significant aims and values.

The clearer your priorities, the more you can focus on them.

On Essentialism, McKeown wrote, The ultimate form of effectiveness is the ability to deliberately invest our time and energy in the few things that matter most.

#2: Set Your Priorities in Order

Prioritize your priorities, not simply know them.

“If you don’t prioritize your life, someone else will.” — Greg McKeown

Planning each day and allocating enough time for your priorities is the best method to become more purposeful.

#3: Practice saying "no"

If a request or demand conflicts with your aims or principles, you must learn to say no.

Saying no frees up space for our priorities.

Place Sleep Above All Else

Many believe they must forego sleep to be more productive. This is false.

A productive day starts with a good night's sleep.

Matthew Walker (Why We Sleep) says:

“Getting a good night’s sleep can improve cognitive performance, creativity, and overall productivity.”

Sleep helps us learn, remember, and repair.

Unfortunately, 35% of people don't receive the recommended 79 hours of sleep per night.

Sleep deprivation can cause:

  • increased risk of diabetes, heart disease, stroke, and obesity

  • Depression, stress, and anxiety risk are all on the rise.

  • decrease in general contentment

  • decline in cognitive function

To live an ideal, productive, and healthy life, you must prioritize sleep.

Follow these six sleep optimization strategies to obtain enough sleep:

  • Establish a nightly ritual to relax and prepare for sleep.

  • Avoid using screens an hour before bed because the blue light they emit disrupts the generation of melatonin, a necessary hormone for sleep.

  • Maintain a regular sleep schedule to control your body's biological clock (and optimizes melatonin production)

  • Create a peaceful, dark, and cool sleeping environment.

  • Limit your intake of sweets and caffeine (especially in the hours leading up to bedtime)

  • Regular exercise (but not right before you go to bed, because your body temperature will be too high)

Sleep is one of the best ways to boost productivity.

Sleep is crucial, says Matthew Walker. It's the key to good health and longevity.

Deon Ashleigh

Deon Ashleigh

2 years ago

You can dominate your daily productivity with these 9 little-known Google Calendar tips.

Calendars are great unpaid employees.

all images (and sloppy handwriting) by the author

After using Notion to organize my next three months' goals, my days were a mess.

I grew very chaotic afterward. I was overwhelmed, unsure of what to do, and wasting time attempting to plan the day after it had started.

Imagine if our skeletons were on the outside. Doesn’t work.

The goals were too big; I needed to break them into smaller chunks. But how?

Enters Google Calendar

RescueTime’s recommendations took me seven hours to make a daily planner. This epic narrative begins with a sheet of paper and concludes with a daily calendar that helps me focus and achieve more goals. Ain’t nobody got time for “what’s next?” all day.

Onward!

Return to the Paleolithic Era

Plan in writing.

handwritten time blocking. has arrows to indicate energy needed or author’s energy at that time of day

Not on the list, but it helped me plan my day. Physical writing boosts creativity and recall.

Find My Heart

i.e. prioritize

RescueTime suggested I prioritize before planning. Personal and business goals were proposed.

My top priorities are to exercise, eat healthily, spend time in nature, and avoid stress.

Priorities include writing and publishing Medium articles, conducting more freelance editing and Medium outreach, and writing/editing sci-fi books.

These eight things will help me feel accomplished every day.

Make a baby calendar.

Create daily calendar templates.

Make family, pleasure, etc. calendars.

Google Calendar instructions:

  • Other calendars

  • Press the “+” button

  • Create a new calendar

  • Create recurring events for each day

My calendar, without the template:

Empty, so I can fill it with vital tasks.

With the template:

Isn’t it awesome how the other calendars overlay the template? :)

My daily skeleton corresponds with my priorities. I've been overwhelmed for years because I lack daily, weekly, monthly, and yearly structure.

Google Calendars helps me reach my goals and focus my energy.

Get your colored pencils ready

Time-block color-coding.

Color labeling lets me quickly see what's happening. Maybe you are too.

Google Calendar instructions:

  • Determine which colors correspond to each time block.

  • When establishing new events, select a color.

  • Save

My calendar is color-coded as follows:

  • Yellow — passive income or other future-related activities

  • Red — important activities, like my monthly breast exam

  • Flamingo — shallow work, like emails, Twitter, etc.

  • Blue — all my favorite activities, like walking, watching comedy, napping, and sleeping. Oh, and eating.

  • Green — money-related events required for this adulting thing

  • Purple — writing-related stuff

Associating a time block with a color helps me stay focused. Less distractions mean faster work.

Open My Email

aka receive a daily email from Google Calendar.

Google Calendar sends a daily email feed of your calendars. I sent myself the template calendar in this email.

Google Calendar instructions:

  • Access settings

  • Select the calendar that you want to send (left side)

  • Go down the page to see more alerts

  • Under the daily agenda area, click Email.

Get in Touch With Your Red Bull Wings — Naturally

aka audit your energy levels.

My daily planner has arrows. These indicate how much energy each activity requires or how much I have.

Rightward arrow denotes medium energy.

I do my Medium and professional editing in the morning because it's energy-intensive.

Niharikaa Sodhi recommends morning Medium editing.

I’m a morning person. As long as I go to bed at a reasonable time, 5 a.m. is super wild GO-TIME. It’s like the world was just born, and I marvel at its wonderfulness.

Freelance editing lets me do what I want. An afternoon snooze will help me finish on time.

Ditch Schedule View

aka focus on the weekly view.

RescueTime advocated utilizing the weekly view of Google Calendar, so I switched.

When you launch the phone app or desktop calendar, a red line shows where you are in the day.

I'll follow the red line's instructions. My digital supervisor is easy to follow.

In the image above, it's almost 3 p.m., therefore the red line implies it's time to snooze.

I won't forget this block ;).

Reduce the Lighting

aka dim previous days.

This is another Google Calendar feature I didn't know about. Once the allotted time passes, the time block dims. This keeps me present.

Google Calendar instructions:

  • Access settings

  • remaining general

  • To view choices, click.

  • Check Diminish the glare of the past.

Bonus

Two additional RescueTimes hacks:

Maintain a space between tasks

I left 15 minutes between each time block to transition smoothly. This relates to my goal of less stress. If I set strict start and end times, I'll be stressed.

With a buffer, I can breathe, stroll around, and start the following time block fresh.

Find a time is related to the buffer.

This option allows you conclude small meetings five minutes early and longer ones ten. Before the next meeting, relax or go wild.

Decide on a backup day.

This productivity technique is amazing.

Spend this excess day catching up on work. It helps reduce tension and clutter.

That's all I can say about Google Calendar's functionality.

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Enrique Dans

Enrique Dans

3 years ago

You may not know about The Merge, yet it could change society

IMAGE: Ethereum.org

Ethereum is the second-largest cryptocurrency. The Merge, a mid-September event that will convert Ethereum's consensus process from proof-of-work to proof-of-stake if all goes according to plan, will be a game changer.

Why is Ethereum ditching proof-of-work? Because it can. We're talking about a fully functioning, open-source ecosystem with a capacity for evolution that other cryptocurrencies lack, a change that would allow it to scale up its performance from 15 transactions per second to 100,000 as its blockchain is used for more and more things. It would reduce its energy consumption by 99.95%. Vitalik Buterin, the system's founder, would play a less active role due to decentralization, and miners, who validated transactions through proof of work, would be far less important.

Why has this conversion taken so long and been so cautious? Because it involves modifying a core process while it's running to boost its performance. It requires running the new mechanism in test chains on an ever-increasing scale, assessing participant reactions, and checking for issues or restrictions. The last big test was in early June and was successful. All that's left is to converge the mechanism with the Ethereum blockchain to conclude the switch.

What's stopping Bitcoin, the leader in market capitalization and the cryptocurrency that began blockchain's appeal, from doing the same? Satoshi Nakamoto, whoever he or she is, departed from public life long ago, therefore there's no community leadership. Changing it takes a level of consensus that is impossible to achieve without strong leadership, which is why Bitcoin's evolution has been sluggish and conservative, with few modifications.

Secondly, The Merge will balance the consensus mechanism (proof-of-work or proof-of-stake) and the system decentralization or centralization. Proof-of-work prevents double-spending, thus validators must buy hardware. The system works, but it requires a lot of electricity and, as it scales up, tends to re-centralize as validators acquire more hardware and the entire network activity gets focused in a few nodes. Larger operations save more money, which increases profitability and market share. This evolution runs opposed to the concept of decentralization, and some anticipate that any system that uses proof of work as a consensus mechanism will evolve towards centralization, with fewer large firms able to invest in efficient network nodes.

Yet radical bitcoin enthusiasts share an opposite argument. In proof-of-stake, transaction validators put their funds at stake to attest that transactions are valid. The algorithm chooses who validates each transaction, giving more possibilities to nodes that put more coins at stake, which could open the door to centralization and government control.

In both cases, we're talking about long-term changes, but Bitcoin's proof-of-work has been evolving longer and seems to confirm those fears, while proof-of-stake is only employed in coins with a minuscule volume compared to Ethereum and has no predictive value.

As of mid-September, we will have two significant cryptocurrencies, each with a different consensus mechanisms and equally different characteristics: one is intrinsically conservative and used only for economic transactions, while the other has been evolving in open source mode, and can be used for other types of assets, smart contracts, or decentralized finance systems. Some even see it as the foundation of Web3.

Many things could change before September 15, but The Merge is likely to be a turning point. We'll have to follow this closely.

Scott Galloway

Scott Galloway

3 years ago

First Health

ZERO GRACE/ZERO MALICE

Amazon's purchase of One Medical could speed up American healthcare

The U.S. healthcare industry is a 7-ton seal bleeding at sea. Predators are circling. Unearned margin: price increases relative to inflation without quality improvements. Amazon is the 11-foot megalodon with 7-inch teeth. Amazon is no longer circling... but attacking.

In 2020 dollars, per capita U.S. healthcare spending increased from $2,968 in 1980 to $12,531. The result is a massive industry with 13% of the nation's workers and a fifth of GDP.

Doctor No

In 40 years, healthcare has made progress. From 73.7 in 1980 to 78.8 in 2019, life expectancy rose (before Covid knocked it back down a bit). Pharmacological therapies have revolutionized, and genetic research is paying off. The financial return, improvement split by cost increases, is terrible. No country has expense rises like the U.S., and no one spends as much per capita as we do. Developed countries have longer life expectancies, healthier populations, and less economic hardship.

Two-thirds of U.S. personal bankruptcies are due to medical expenses and/or missed work. Mom or Dad getting cancer could bankrupt many middle-class American families. 40% of American adults delayed or skipped needed care due to cost. Every healthcare improvement seems to have a downside. Same pharmacological revolution that helped millions caused opioid epidemic. Our results are poor in many areas: The U.S. has a high infant mortality rate.

Healthcare is the second-worst retail industry in the country. Gas stations are #1. Imagine walking into a Best Buy to buy a TV and a Blue Shirt associate requests you fill out the same 14 pages of paperwork you filled out yesterday. Then you wait in a crowded room until they call you, 20 minutes after the scheduled appointment you were asked to arrive early for, to see the one person in the store who can talk to you about TVs, who has 10 minutes for you. The average emergency room wait time in New York is 6 hours and 10 minutes.

If it's bad for the customer, it's worse for the business. Physicians spend 27% of their time helping patients; 49% on EHRs. Documentation, order entry, billing, and inbox management. Spend a decade getting an M.D., then become a bureaucrat.

No industry better illustrates scale diseconomies. If we got the same return on healthcare spending as other countries, we'd all live to 100. We could spend less, live longer and healthier, and pay off the national debt in 15 years. U.S. healthcare is the worst ever.

What now? Competition is at the heart of capitalism, the worst system of its kind.

Priority Time

Amazon is buying One Medical for $3.9 billion. I think this deal will liberate society. Two years in, I think One Medical is great. When I got Covid, I pressed the One Medical symbol on my phone; a nurse practitioner prescribed Paxlovid and told me which pharmacies had it in stock.

Amazon enables the company's vision. One Medical's stock is down to $10 from $40 at the start of 2021. Last year, it lost $250 million and needs cash (Amazon has $60 billion). ONEM must grow. The service has 736,000 members. Half of U.S. households have Amazon Prime. Finally, delivery. One Medical is a digital health/physical office hybrid, but you must pick up medication at the pharmacy. Upgrade your Paxlovid delivery time after a remote consultation. Amazon's core competency means it'll happen. Healthcare speed and convenience will feel alien.

It's been a long, winding road to disruption. Amazon, JPMorgan, and Berkshire Hathaway formed Haven four years ago to provide better healthcare for their 1.5 million employees. It rocked healthcare stocks the morning of the press release, but folded in 2021.

Amazon Care is an employee-focused service. Home-delivered virtual health services and nurses. It's doing well, expanding nationwide, and providing healthcare for other companies. Hilton is Amazon Care's biggest customer. The acquisition of One Medical will bring 66 million Prime households capital, domain expertise, and billing infrastructure. Imagine:

"Alexa, I'm hot and my back hurts."

"Connecting you to a Prime doctor now."

Want to vs. Have to

I predicted Amazon entering healthcare years ago. Why? For the same reason Apple is getting into auto. Amazon's P/E is 56, double Walmart's. The corporation must add $250 billion in revenue over the next five years to retain its share price. White-label clothes or smart home products won't generate as much revenue. It must enter a huge market without scale, operational competence, and data skills.

Current Situation

Healthcare reform benefits both consumers and investors. In 2015, healthcare services had S&P 500-average multiples. The market is losing faith in public healthcare businesses' growth. Healthcare services have lower EV/EBITDA multiples than the S&P 500.

Amazon isn't the only prey-hunter. Walmart and Alibaba are starting pharmacies. Uber is developing medical transportation. Private markets invested $29 billion in telehealth last year, up 95% from 2020.

The pandemic accelerated telehealth, the immediate unlock. After the first positive Covid case in the U.S., services that had to be delivered in person shifted to Zoom... We lived. We grew. Video house calls continued after in-person visits were allowed. McKinsey estimates telehealth visits are 38 times pre-pandemic levels. Doctors adopted the technology, regulators loosened restrictions, and patients saved time. We're far from remote surgery, but many patient visits are unnecessary. A study of 40 million patients during lockdown found that for chronic disease patients, online visits didn't affect outcomes. This method of care will only improve.

Amazon's disruption will be significant and will inspire a flood of capital, startups, and consumer brands. Mark Cuban launched a pharmacy that eliminates middlemen in January. Outcome? A 90-day supply of acid-reflux medication costs $17. Medicare could have saved $3.6 billion by buying generic drugs from Cuban's pharmacy. Other apex predators will look at different limbs of the carcass for food. Nike could enter healthcare via orthopedics, acupuncture, and chiropractic. LVMH, L'Oréal, and Estée Lauder may launch global plastic surgery brands. Hilton and Four Seasons may open hospitals. Lennar and Pulte could build "Active Living" communities that Nana would leave feet first, avoiding the expense and tragedy of dying among strangers.

Risks

Privacy matters: HIV status is different from credit card and billing address. Most customers (60%) feel fine sharing personal health data via virtual technologies, though. Unavoidable. 85% of doctors believe data-sharing and interoperability will become the norm. Amazon is the most trusted tech company for handling personal data. Not Meta: Amazon.

What about antitrust, then?

Amazon should be required to spin off AWS and/or Amazon Fulfillment and banned from promoting its own products. It should be allowed to acquire hospitals. One Medical's $3.9 billion acquisition is a drop in the bucket compared to UnitedHealth's $498 billion market valuation.

Antitrust enforcement shouldn't assume some people/firms are good/bad. It should recognize that competition is good and focus on making markets more competitive in each deal. The FTC should force asset divestitures in e-commerce, digital marketing, and social media. These companies can also promote competition in a social ill.

U.S. healthcare makes us fat, depressed, and broke. Competition has produced massive value and prosperity across most of our economy.

Dear Amazon … bring it.

Laura Sanders

Laura Sanders

3 years ago

Xenobots, tiny living machines, can duplicate themselves.

Strange and complex behavior of frog cell blobs


A xenobot “parent,” shaped like a hungry Pac-Man (shown in red false color), created an “offspring” xenobot (green sphere) by gathering loose frog cells in its opening.

Tiny “living machines” made of frog cells can make copies of themselves. This newly discovered renewal mechanism may help create self-renewing biological machines.

According to Kirstin Petersen, an electrical and computer engineer at Cornell University who studies groups of robots, “this is an extremely exciting breakthrough.” She says self-replicating robots are a big step toward human-free systems.

Researchers described the behavior of xenobots earlier this year (SN: 3/31/21). Small clumps of skin stem cells from frog embryos knitted themselves into small spheres and started moving. Cilia, or cellular extensions, powered the xenobots around their lab dishes.

The findings are published in the Proceedings of the National Academy of Sciences on Dec. 7. The xenobots can gather loose frog cells into spheres, which then form xenobots.
The researchers call this type of movement-induced reproduction kinematic self-replication. The study's coauthor, Douglas Blackiston of Tufts University in Medford, Massachusetts, and Harvard University, says this is typical. For example, sexual reproduction requires parental sperm and egg cells. Sometimes cells split or budded off from a parent.

“This is unique,” Blackiston says. These xenobots “find loose parts in the environment and cobble them together.” This second generation of xenobots can move like their parents, Blackiston says.
The researchers discovered that spheroid xenobots could only produce one more generation before dying out. The original xenobots' shape was predicted by an artificial intelligence program, allowing for four generations of replication.

A C shape, like an openmouthed Pac-Man, was predicted to be a more efficient progenitor. When improved xenobots were let loose in a dish, they began scooping up loose cells into their gaping “mouths,” forming more sphere-shaped bots (see image below). As many as 50 cells clumped together in the opening of a parent to form a mobile offspring. A xenobot is made up of 4,000–6,000 frog cells.

Petersen likes the Xenobots' small size. “The fact that they were able to do this at such a small scale just makes it even better,” she says. Miniature xenobots could sculpt tissues for implantation or deliver therapeutics inside the body.

Beyond the xenobots' potential jobs, the research advances an important science, says study coauthor and Tufts developmental biologist Michael Levin. The science of anticipating and controlling the outcomes of complex systems, he says.

“No one could have predicted this,” Levin says. “They regularly surprise us.” Researchers can use xenobots to test the unexpected. “This is about advancing the science of being less surprised,” Levin says.