More on Entrepreneurship/Creators

Sanjay Priyadarshi
3 years ago
Meet a Programmer Who Turned Down Microsoft's $10,000,000,000 Acquisition Offer
Failures inspire young developers
Jason citron created many products.
These products flopped.
Microsoft offered $10 billion for one of these products.
He rejected the offer since he was so confident in his success.
Let’s find out how he built a product that is currently valued at $15 billion.
Early in his youth, Jason began learning to code.
Jason's father taught him programming and IT.
His father wanted to help him earn money when he needed it.
Jason created video games and websites in high school.
Jason realized early on that his IT and programming skills could make him money.
Jason's parents misjudged his aptitude for programming.
Jason frequented online programming communities.
He looked for web developers. He created websites for those people.
His parents suspected Jason sold drugs online. When he said he used programming to make money, they were shocked.
They helped him set up a PayPal account.
Florida higher education to study video game creation
Jason never attended an expensive university.
He studied game design in Florida.
“Higher Education is an interesting part of society… When I work with people, the school they went to never comes up… only thing that matters is what can you do…At the end of the day, the beauty of silicon valley is that if you have a great idea and you can bring it to the life, you can convince a total stranger to give you money and join your project… This notion that you have to go to a great school didn’t end up being a thing for me.”
Jason's life was altered by Steve Jobs' keynote address.
After graduating, Jason joined an incubator.
Jason created a video-dating site first.
Bad idea.
Nobody wanted to use it when it was released, so they shut it down.
He made a multiplayer game.
It was released on Bebo. 10,000 people played it.
When Steve Jobs unveiled the Apple app store, he stopped playing.
The introduction of the app store resembled that of a new gaming console.
Jason's life altered after Steve Jobs' 2008 address.
“Whenever a new video game console is launched, that’s the opportunity for a new video game studio to get started, it’s because there aren’t too many games available…When a new PlayStation comes out, since it’s a new system, there’s only a handful of titles available… If you can be a launch title you can get a lot of distribution.”
Apple's app store provided a chance to start a video game company.
They released an app after 5 months of work.
Aurora Feint is the game.
Jason believed 1000 players in a week would be wonderful. A thousand players joined in the first hour.
Over time, Aurora Feints' game didn't gain traction. They don't make enough money to keep playing.
They could only make enough for one month.
Instead of buying video games, buy technology
Jason saw that they established a leaderboard, chat rooms, and multiplayer capabilities and believed other developers would want to use these.
They opted to sell the prior game's technology.
OpenFeint.
Assisting other game developers
They had no money in the bank to create everything needed to make the technology user-friendly.
Jason and Daniel designed a website saying:
“If you’re making a video game and want to have a drop in multiplayer support, you can use our system”
TechCrunch covered their website launch, and they gained a few hundred mailing list subscribers.
They raised seed funding with the mailing list.
Nearly all iPhone game developers started adopting the Open Feint logo.
“It was pretty wild… It was really like a whole social platform for people to play with their friends.”
What kind of a business model was it?
OpenFeint originally planned to make the software free for all games. As the game gained popularity, they demanded payment.
They later concluded it wasn't a good business concept.
It became free eventually.
Acquired for $104 million
Open Feint's users and employees grew tremendously.
GREE bought OpenFeint for $104 million in April 2011.
GREE initially committed to helping Jason and his team build a fantastic company.
Three or four months after the acquisition, Jason recognized they had a different vision.
He quit.
Jason's Original Vision for the iPad
Jason focused on distribution in 2012 to help businesses stand out.
The iPad market and user base were growing tremendously.
Jason said the iPad may replace mobile gadgets.
iPad gamers behaved differently than mobile gamers.
People sat longer and experienced more using an iPad.
“The idea I had was what if we built a gaming business that was more like traditional video games but played on tablets as opposed to some kind of mobile game that I’ve been doing before.”
Unexpected insight after researching the video game industry
Jason learned from studying the gaming industry that long-standing companies had advantages beyond a single release.
Previously, long-standing video game firms had their own distribution system. This distribution strategy could buffer time between successful titles.
Sony, Microsoft, and Valve all have gaming consoles and online stores.
So he built a distribution system.
He created a group chat app for gamers.
He envisioned a team-based multiplayer game with text and voice interaction.
His objective was to develop a communication network, release more games, and start a game distribution business.
Remaking the video game League of Legends
Jason and his crew reimagined a League of Legends game mode for 12-inch glass.
They adapted the game for tablets.
League of Legends was PC-only.
So they rebuilt it.
They overhauled the game and included native mobile experiences to stand out.
Hammer and Chisel was the company's name.
18 people worked on the game.
The game was funded. The game took 2.5 years to make.
Was the game a success?
July 2014 marked the game's release. The team's hopes were dashed.
Critics initially praised the game.
Initial installation was widespread.
The game failed.
As time passed, the team realized iPad gaming wouldn't increase much and mobile would win.
Jason was given a fresh idea by Stan Vishnevskiy.
Stan Vishnevskiy was a corporate engineer.
He told Jason about his plan to design a communication app without a game.
This concept seeded modern strife.
“The insight that he really had was to put a couple of dots together… we’re seeing our customers communicating around our own game with all these different apps and also ourselves when we’re playing on PC… We should solve that problem directly rather than needing to build a new game…we should start making it on PC.”
So began Discord.
Online socializing with pals was the newest trend.
Jason grew up playing video games with his friends.
He never played outside.
Jason had many great moments playing video games with his closest buddy, wife, and brother.
Discord was about providing a location for you and your group to speak and hang out.
Like a private cafe, bedroom, or living room.
Discord was developed for you and your friends on computers and phones.
You can quickly call your buddies during a game to conduct a conference call. Put the call on speaker and talk while playing.
Discord wanted to give every player a unique experience. Because coordinating across apps was a headache.
The entire team started concentrating on Discord.
Jason decided Hammer and Chisel would focus on their chat app.
Jason didn't want to make a video game.
How Discord attracted the appropriate attention
During the first five months, the entire team worked on the game and got feedback from friends.
This ensures product improvement. As a result, some teammates' buddies started utilizing Discord.
The team knew it would become something, but the result was buggy. App occasionally crashed.
Jason persuaded a gamer friend to write on Reddit about the software.
New people would find Discord. Why not?
Reddit users discovered Discord and 50 started using it frequently.
Discord was launched.
Rejecting the $10 billion acquisition proposal
Discord has increased in recent years.
It sends billions of messages.
Discord's users aren't tracked. They're privacy-focused.
Purchase offer
Covid boosted Discord's user base.
Weekly, billions of messages were transmitted.
Microsoft offered $10 billion for Discord in 2021.
Jason sold Open Feint for $104m in 2011.
This time, he believed in the product so much that he rejected Microsoft's offer.
“I was talking to some people in the team about which way we could go… The good thing was that most of the team wanted to continue building.”
Last time, Discord was valued at $15 billion.
Discord raised money on March 12, 2022.
The $15 billion corporation raised $500 million in 2021.

Alex Mathers
2 years ago
400 articles later, nobody bothered to read them.
Writing for readers:
14 years of daily writing.
I post practically everything on social media. I authored hundreds of articles, thousands of tweets, and numerous volumes to almost no one.
Tens of thousands of readers regularly praise me.
I despised writing. I'm stuck now.
I've learned what readers like and what doesn't.
Here are some essential guidelines for writing with impact:
Readers won't understand your work if you can't.
Though obvious, this slipped me up. Share your truths.
Stories engage human brains.
Showing the journey of a person from worm to butterfly inspires the human spirit.
Overthinking hinders powerful writing.
The best ideas come from inner understanding in between thoughts.
Avoid writing to find it. Write.
Writing a masterpiece isn't motivating.
Write for five minutes to simplify. Step-by-step, entertaining, easy steps.
Good writing requires a willingness to make mistakes.
So write loads of garbage that you can edit into a good piece.
Courageous writing.
A courageous story will move readers. Personal experience is best.
Go where few dare.
Templates, outlines, and boundaries help.
Limitations enhance writing.
Excellent writing is straightforward and readable, removing all the unnecessary fat.
Use five words instead of nine.
Use ordinary words instead of uncommon ones.
Readers desire relatability.
Too much perfection will turn it off.
Write to solve an issue if you can't think of anything to write.
Instead, read to inspire. Best authors read.
Every tweet, thread, and novel must have a central idea.
What's its point?
This can make writing confusing.
️ Don't direct your reader.
Readers quit reading. Demonstrate, describe, and relate.
Even if no one responds, have fun. If you hate writing it, the reader will too.

ʟ ᴜ ᴄ ʏ
3 years ago
The Untapped Gold Mine of Inspiration and Startup Ideas
I joined the 1000 Digital Startups Movement (Gerakan 1000 Startup Digital) in 2017 and learned a lot about the startup sector. My previous essay outlined what a startup is and what must be prepared. Here I'll offer raw ideas for better products.
Intro
A good startup solves a problem. These can include environmental, economic, energy, transportation, logistics, maritime, forestry, livestock, education, tourism, legal, arts and culture, communication, and information challenges. Everything I wrote is simply a basic idea (as inspiration) and requires more mapping and validation. Learn how to construct a startup to maximize launch success.
Adrian Gunadi (Investree Co-Founder) taught me that a Founder or Co-Founder must be willing to be CEO (Chief Everything Officer). Everything is independent, including drafting a proposal, managing finances, and scheduling appointments. The best individuals will come to you if you're the best. It's easier than consulting Andy Zain (Kejora Capital Founder).
Description
To help better understanding from your idea, try to answer this following questions:
- Describe your idea/application
Maximum 1000 characters.
- Background
Explain the reasons that prompted you to realize the idea/application.
- Objective
Explain the expected goals of the creation of the idea/application.
- Solution
A solution that tells your idea can be the right solution for the problem at hand.
- Uniqueness
What makes your idea/app unique?
- Market share
Who are the people who need and are looking for your idea?
- Marketing Ways and Business Models
What is the best way to sell your idea and what is the business model?
Not everything here is a startup idea. It's meant to inspire creativity and new perspectives.
Ideas
#Application
1. Medical students can operate on patients or not. Applications that train prospective doctors to distinguish body organs and their placement are useful. In the advanced stage, the app can be built with numerous approaches so future doctors can practice operating on patients based on their ailments. If they made a mistake, they'd start over. Future doctors will be more assured and make fewer mistakes this way.
2. VR (virtual reality) technology lets people see 3D space from afar. Later, similar technology was utilized to digitally sell properties, so buyers could see the inside and room contents. Every gadget has flaws. It's like a gold mine for robbers. VR can let prospective students see a campus's facilities. This facility can also help hotels promote their products.
3. How can retail entrepreneurs maximize sales? Most popular goods' sales data. By using product and brand/type sales figures, entrepreneurs can avoid overstocking. Walmart computerized their procedures to track products from the manufacturer to the store. As Retail Link products sell out, suppliers can immediately step in.
4. Failing to marry is something to be avoided. But if it had to happen, the loss would be like the proverb “rub salt into the wound”. On the I do Now I dont website, Americans who don't marry can resell their jewelry to other brides-to-be. If some want to cancel the wedding and receive their down money and dress back, others want a wedding with particular criteria, such as a quick date and the expected building. Create a DP takeover marketplace for both sides.
#Games
1. Like in the movie, players must exit the maze they enter within 3 minutes or the shape will change, requiring them to change their strategy. The maze's transformation time will shorten after a few stages.
2. Treasure hunts involve following clues to uncover hidden goods. Here, numerous sponsors are combined in one boat, and participants can choose a game based on the prizes. Let's say X-mart is a sponsor and provides riddles or puzzles to uncover the prize in their store. After gathering enough points, the player can trade them for a gift utilizing GPS and AR (augmented reality). Players can collaborate to increase their chances of success.
3. Where's Wally? Where’s Wally displays a thick image with several things and various Wally-like characters. We must find the actual Wally, his companions, and the desired object. Make a game with a map where players must find objects for the next level. The player must find 5 artifacts randomly placed in an Egyptian-style mansion, for example. In the room, there are standard tickets, pass tickets, and gold tickets that can be removed for safekeeping, as well as a wall-mounted carpet that can be stored but not searched and turns out to be a flying rug that can be used to cross/jump to a different place. Regular tickets are spread out since they can buy life or stuff. At a higher level, a black ticket can lower your ordinary ticket. Objects can explode, scattering previously acquired stuff. If a player runs out of time, they can exchange a ticket for more.
#TVprogram
1. At the airport there are various visitors who come with different purposes. Asking tourists to live for 1 or 2 days in the city will be intriguing to witness.
2. Many professions exist. Carpenters, cooks, and lawyers must have known about job desks. Does HRD (Human Resource Development) only recruit new employees? Many don't know how to become a CEO, CMO, COO, CFO, or CTO. Showing young people what a Program Officer in an NGO does can help them choose a career.
#StampsCreations
Philatelists know that only the government can issue stamps. I hope stamps are creative so they have more worth.
1. Thermochromic pigments (leuco dyes) are well-known for their distinctive properties. By putting pigments to black and white batik stamps, for example, the black color will be translucent and display the basic color when touched (at a hot temperature).
2. In 2012, Liechtenstein Post published a laser-art Chinese zodiac stamp. Belgium (Bruges Market Square 2012), Taiwan (Swallow Tail Butterfly 2009), etc. Why not make a stencil of the president or king/queen?
3. Each country needs its unique identity, like Taiwan's silk and bamboo stamps. Create from your country's history. Using traditional paper like washi (Japan), hanji (Korea), and daluang/saeh (Indonesia) can introduce a country's culture.
4. Garbage has long been a problem. Bagasse, banana fronds, or corn husks can be used as stamp material.
5. Austria Post published a stamp containing meteor dust in 2006. 2004 meteorite found in Morocco produced the dust. Gibraltar's Rock of Gilbraltar appeared on stamps in 2002. What's so great about your country? East Java is muddy (Lapindo mud). Lapindo mud stamps will be popular. Red sand at Pink Beach, East Nusa Tenggara, could replace the mud.
#PostcardCreations
1. Map postcards are popular because they make searching easier. Combining laser-cut road map patterns with perforated 200-gram paper glued on 400-gram paper as a writing medium. Vision-impaired people can use laser-cut maps.
2. Regional art can be promoted by tucking traditional textiles into postcards.
3. A thin canvas or plain paper on the card's front allows the giver to be creative.
4. What is local crop residue? Cork lids, maize husks, and rice husks can be recycled into postcard materials.
5. Have you seen a dried-flower bookmark? Cover the postcard with mica and add dried flowers. If you're worried about losing the flowers, you can glue them or make a postcard envelope.
6. Wood may be ubiquitous; try a 0.2-mm copper plate engraved with an image and connected to a postcard as a writing medium.
7. Utilized paper pulp can be used to hold eggs, smartphones, and food. Form a smooth paper pulp on the plate with the desired image, the Golden Gate bridge, and paste it on your card.
8. Postcards can promote perfume. When customers rub their hands on the card with the perfume image, they'll smell the aroma.
#Tour #Travel
Tourism activities can be tailored to tourists' interests or needs. Each tourist benefits from tourism's distinct aim.
Let's define tourism's objective and purpose.
Holiday Tour is a tour that its participants plan and do in order to relax, have fun, and amuse themselves.
A familiarization tour is a journey designed to help travelers learn more about (survey) locales connected to their line of work.
An educational tour is one that aims to give visitors knowledge of the field of work they are visiting or an overview of it.
A scientific field is investigated and knowledge gained as the major goal of a scientific tour.
A pilgrimage tour is one designed to engage in acts of worship.
A special mission tour is one that has a specific goal, such a commerce mission or an artistic endeavor.
A hunting tour is a destination for tourists that plans organized animal hunting that is only allowed by local authorities for entertainment purposes.
Every part of life has tourism potential. Activities include:
1. Those who desire to volunteer can benefit from the humanitarian theme and collaboration with NGOs. This activity's profit isn't huge but consider the environmental impact.
2. Want to escape the city? Meditation travel can help. Beautiful spots around the globe can help people forget their concerns. A certified yoga/meditation teacher can help travelers release bad energy.
3. Any prison visitors? Some prisons, like those for minors under 17, are open to visitors. This type of tourism helps mental convicts reach a brighter future.
4. Who has taken a factory tour/study tour? Outside-of-school study tour (for ordinary people who have finished their studies). Not everyone in school could tour industries, workplaces, or embassies to learn and be inspired. Shoyeido (an incense maker) and Royce (a chocolate maker) offer factory tours in Japan.
5. Develop educational tourism like astronomy and archaeology. Until now, only a few astronomy enthusiasts have promoted astronomy tourism. In Indonesia, archaeology activities focus on site preservation, and to participate, office staff must undertake a series of training (not everyone can take a sabbatical from their routine). Archaeological tourist activities are limited, whether held by history and culture enthusiasts or in regional tours.
6. Have you ever longed to observe a film being made or your favorite musician rehearsing? Such tours can motivate young people to pursue entertainment careers.
7. Pamper your pets to reduce stress. Many pet owners don't have time for walks or treats. These premium services target the wealthy.
8. A quirky idea to provide tours for imaginary couples or things. Some people marry inanimate objects or animals and seek to make their lover happy; others cherish their ashes after death.
#MISCideas
1. Fashion is a lifestyle, thus people often seek fresh materials. Chicken claws, geckos, snake skin casings, mice, bats, and fish skins are also used. Needs some improvement, definitely.
2. As fuel supplies become scarcer, people hunt for other energy sources. Sound is an underutilized renewable energy. The Batechsant technology converts environmental noise into electrical energy, according to study (Battery Technology Of Sound Power Plant). South Korean researchers use Sound-Driven Piezoelectric Nanowire based on Nanogenerators to recharge cell phone batteries. The Batechsant system uses existing noise levels to provide electricity for street lamp lights, aviation, and ships. Using waterfall sound can also energize hard-to-reach locations.
3. A New York Times reporter said IQ doesn't ensure success. Our school system prioritizes IQ above EQ (Emotional Quotient). EQ is a sort of human intelligence that allows a person to perceive and analyze the dynamics of his emotions when interacting with others (and with himself). EQ is suspected of being a bigger source of success than IQ. EQ training can gain greater attention to help people succeed. Prioritize role models from school stakeholders, teachers, and parents to improve children' EQ.
4. Teaching focuses more on theory than practice, so students are less eager to explore and easily forget if they don't pay attention. Has an engineer ever made bricks from arid red soil? Morocco's non-college-educated builders can create weatherproof bricks from red soil without equipment. Can mechanical engineering grads create a water pump to solve water shortages in remote areas? Art graduates can innovate beyond only painting. Artists may create kinetic sculpture by experimenting so much. Young people should understand these sciences so they can be more creative with their potential. These might be extracurricular activities in high school and university.
5. People have been trying to recycle agricultural waste for a long time. Mycelium helps replace light, easily crushed tiles and bricks (a collection of hyphae like in the manufacture of tempe). Waste must contain lignocellulose. In this vein, anti-mainstream painting canvases can be made. The goal is to create the canvas uneven like an amoeba outline, not square or spherical. The resulting canvas is lightweight and needs no frame. Then what? Open source your idea like Precious Plastic to establish a community. By propagating this notion, many knowledgeable people will help improve your product's quality and impact.
6. As technology and humans adapt, fraud increases. Making phony doctor's letters to fool superiors, fake credentials to get hired, fraudulent land certificates to make money, and fake news (hoax). The existence of a Wikimedia can aid the community by comparing bogus and original information.
7. Do you often hit a problem-solving impasse? Since the Doraemon bag hasn't been made, construct an Idea Bank. Everyone can contribute to solving problems here. How do you recruit volunteers? Obviously, a reward is needed. Contributors can become moderators or gain complimentary tickets to TIA (Tech in Asia) conferences. Idea Bank-related concepts: the rise of startups without a solid foundation generates an age as old as corn that does not continue. Those with startup ideas should describe them here so they can be validated by other users. Other users can contribute input if a comparable notion is produced to improve the product or integrate it. Similar-minded users can become Co-Founders.
8. Why not invest in fruit/vegetables, inspired by digital farming? The landowner obtains free fruit without spending much money on maintenance. Investors can get fruits/vegetables in larger quantities, fresher, and cheaper during harvest. Fruits and vegetables are often harmed if delivered too slowly. Rich investors with limited land can invest in teak, agarwood, and other trees. When harvesting, investors might choose raw results or direct wood sales earnings. Teak takes at least 7 years to harvest, therefore long-term wood investments carry the risk of crop failure.
9. Teenagers in distant locations can't count, read, or write. Many factors hinder locals' success. Life's demands force them to work instead of study. Creating a learning playground may attract young people to learning. Make a skatepark at school. Skateboarders must learn in school. Donations buy skateboards.
10. Globally, online taxi-bike is known. By hiring a motorcycle/car online, people no longer bother traveling without a vehicle. What if you wish to cross the island or visit remote areas? Is online boat or helicopter rental possible like online taxi-bike? Such a renting process has been done independently thus far and cannot be done quickly.
11. What do startups need now? A startup or investor consultant. How many startups fail to become Unicorns? Many founders don't know how to manage investor money, therefore they waste it on promotions and other things. Many investors only know how to invest and can't guide a struggling firm.
“In times of crisis, the wise build bridges, while the foolish build barriers.” — T’Challa [Black Panther]
Don't chase cash. Money is a byproduct. Profit-seeking is stressful. Market requirements are opportunities. If you have something to say, please comment.
This is only informational. Before implementing ideas, do further study.
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Dmytro Spilka
3 years ago
Why NFTs Have a Bright Future Away from Collectible Art After Punks and Apes
After a crazy second half of 2021 and significant trade volumes into 2022, the market for NFT artworks like Bored Ape Yacht Club, CryptoPunks, and Pudgy Penguins has begun a sharp collapse as market downturns hit token values.
DappRadar data shows NFT monthly sales have fallen below $1 billion since June 2021. OpenSea, the world's largest NFT exchange, has seen sales volume decline 75% since May and is trading like July 2021.
Prices of popular non-fungible tokens have also decreased. Bored Ape Yacht Club (BAYC) has witnessed volume and sales drop 63% and 15%, respectively, in the past month.
BeInCrypto analysis shows market decline. May 2022 cryptocurrency marketplace volume was $4 billion, according to a news platform. This is a sharp drop from April's $7.18 billion.
OpenSea, a big marketplace, contributed $2.6 billion, while LooksRare, Magic Eden, and Solanart also contributed.
NFT markets are digital platforms for buying and selling tokens, similar stock trading platforms. Although some of the world's largest exchanges offer NFT wallets, most users store their NFTs on their favorite marketplaces.
In January 2022, overall NFT sales volume was $16.57 billion, with LooksRare contributing $11.1 billion. May 2022's volume was $12.57 less than January, a 75% drop, and June's is expected to be considerably smaller.
A World Based on Utility
Despite declines in NFT trading volumes, not all investors are negative on NFTs. Although there are uncertainties about the sustainability of NFT-based art collections, there are fewer reservations about utility-based tokens and their significance in technology's future.
In June, business CEO Christof Straub said NFTs may help artists monetize unreleased content, resuscitate catalogs, establish deeper fan connections, and make processes more efficient through technology.
We all know NFTs can't be JPEGs. Straub noted that NFT music rights can offer more equitable rewards to musicians.
Music NFTs are here to stay if they have real value, solve real problems, are trusted and lawful, and have fair and sustainable business models.
NFTs can transform numerous industries, including music. Market opinion is shifting towards tokens with more utility than the social media artworks we're used to seeing.
While the major NFT names remain dominant in terms of volume, new utility-based initiatives are emerging as top 20 collections.
Otherdeed, Sorare, and NBA Top Shot are NFT-based games that rank above Bored Ape Yacht Club and Cryptopunks.
Users can switch video NFTs of basketball players in NBA Top Shot. Similar efforts are emerging in the non-fungible landscape.
Sorare shows how NFTs can support a new way of playing fantasy football, where participants buy and swap trading cards to create a 5-player team that wins rewards based on real-life performances.
Sorare raised 579.7 million in one of Europe's largest Series B financing deals in September 2021. Recently, the platform revealed plans to expand into Major League Baseball.
Strong growth indications suggest a promising future for NFTs. The value of art-based collections like BAYC and CryptoPunks may be questioned as markets become diluted by new limited collections, but the potential for NFTs to become intrinsically linked to tangible utility like online gaming, music and art, and even corporate reward schemes shows the industry has a bright future.

Michael Hunter, MD
3 years ago
5 Drugs That May Increase Your Risk of Dementia
While our genes can't be changed easily, you can avoid some dementia risk factors. Today we discuss dementia and five drugs that may increase risk.
Memory loss appears to come with age, but we're not talking about forgetfulness. Sometimes losing your car keys isn't an indication of dementia. Dementia impairs the capacity to think, remember, or make judgments. Dementia hinders daily tasks.
Alzheimers is the most common dementia. Dementia is not normal aging, unlike forgetfulness. Aging increases the risk of Alzheimer's and other dementias. A family history of the illness increases your risk, according to the Mayo Clinic (USA).
Given that our genes are difficult to change (I won't get into epigenetics), what are some avoidable dementia risk factors? Certain drugs may cause cognitive deterioration.
Today we look at four drugs that may cause cognitive decline.
Dementia and benzodiazepines
Benzodiazepine sedatives increase brain GABA levels. Example benzodiazepines:
Diazepam (Valium) (Valium)
Alprazolam (Xanax) (Xanax)
Clonazepam (Klonopin) (Klonopin)
Addiction and overdose are benzodiazepine risks. Yes! These medications don't raise dementia risk.
USC study: Benzodiazepines don't increase dementia risk in older adults.
Benzodiazepines can produce short- and long-term amnesia. This memory loss hinders memory formation. Extreme cases can permanently impair learning and memory. Anterograde amnesia is uncommon.
2. Statins and dementia
Statins reduce cholesterol. They prevent a cholesterol-making chemical. Examples:
Atorvastatin (Lipitor) (Lipitor)
Fluvastatin (Lescol XL) (Lescol XL)
Lovastatin (Altoprev) (Altoprev)
Pitavastatin (Livalo, Zypitamag) (Livalo, Zypitamag)
Pravastatin (Pravachol) (Pravachol)
Rosuvastatin (Crestor, Ezallor) (Crestor, Ezallor)
Simvastatin (Zocor) (Zocor)
This finding is contentious. Harvard's Brigham and Womens Hospital's Dr. Joann Manson says:
“I think that the relationship between statins and cognitive function remains controversial. There’s still not a clear conclusion whether they help to prevent dementia or Alzheimer’s disease, have neutral effects, or increase risk.”
This one's off the dementia list.
3. Dementia and anticholinergic drugs
Anticholinergic drugs treat many conditions, including urine incontinence. Drugs inhibit acetylcholine (a brain chemical that helps send messages between cells). Acetylcholine blockers cause drowsiness, disorientation, and memory loss.
First-generation antihistamines, tricyclic antidepressants, and overactive bladder antimuscarinics are common anticholinergics among the elderly.
Anticholinergic drugs may cause dementia. One study found that taking anticholinergics for three years or more increased the risk of dementia by 1.54 times compared to three months or less. After stopping the medicine, the danger may continue.
4. Drugs for Parkinson's disease and dementia
Cleveland Clinic (USA) on Parkinson's:
Parkinson's disease causes age-related brain degeneration. It causes delayed movements, tremors, and balance issues. Some are inherited, but most are unknown. There are various treatment options, but no cure.
Parkinson's medications can cause memory loss, confusion, delusions, and obsessive behaviors. The drug's effects on dopamine cause these issues.
A 2019 JAMA Internal Medicine study found powerful anticholinergic medications enhance dementia risk.
Those who took anticholinergics had a 1.5 times higher chance of dementia. Individuals taking antidepressants, antipsychotic drugs, anti-Parkinson’s drugs, overactive bladder drugs, and anti-epileptic drugs had the greatest risk of dementia.
Anticholinergic medicines can lessen Parkinson's-related tremors, but they slow cognitive ability. Anticholinergics can cause disorientation and hallucinations in those over 70.
5. Antiepileptic drugs and dementia
The risk of dementia from anti-seizure drugs varies with drugs. Levetiracetam (Keppra) improves Alzheimer's cognition.
One study linked different anti-seizure medications to dementia. Anti-epileptic medicines increased the risk of Alzheimer's disease by 1.15 times in the Finnish sample and 1.3 times in the German population. Depakote, Topamax are drugs.

Akshad Singi
3 years ago
Four obnoxious one-minute habits that help me save more than 30 hours each week
These four, when combined, destroy procrastination.
You're not rushed. You waste it on busywork.
You'll accept this eventually.
In 2022, the daily average usage of a user on social media is 2.5 hours.
By 2020, 6 billion hours of video were watched each month by Netflix's customers, who used the service an average of 3.2 hours per day.
When we see these numbers, we think "Wow!" People squander so much time as though they don't contribute. True. These are yours. Likewise.
We don't lack time; we just waste it. Once you realize this, you can change your habits to save time. This article explains. If you adopt ALL 4 of these simple behaviors, you'll see amazing benefits.
Time-blocking
Cal Newport's time-blocking trick takes a minute but improves your day's clarity.
Divide the next day into 30-minute (or 5-minute, if you're Elon Musk) segments and assign responsibilities. As seen.
Here's why:
The procrastination that results from attempting to determine when to begin working is eliminated. Procrastination is a given if you choose when to begin working in real-time. Even if you may assume you'll start working in five minutes, it won't take you long to realize that five minutes have turned into an hour. But if you've already determined to start working at 2:00 the next day, your odds of procrastinating are greatly decreased, if not eliminated altogether.
You'll also see that you have a lot of time in a day when you plan your day out on paper and assign chores to each hour. Doing this daily will permanently eliminate the lack of time mindset.
5-4-3-2-1: Have breakfast with the frog!
“If it’s your job to eat a frog, it’s best to do it first thing in the morning. And If it’s your job to eat two frogs, it’s best to eat the biggest one first.”
Eating the frog means accomplishing the day's most difficult chore. It's better to schedule it first thing in the morning when time-blocking the night before. Why?
The day's most difficult task is also the one that causes the most postponement. Because of the stress it causes, the later you schedule it, the more time you risk wasting by procrastinating.
However, if you do it right away in the morning, you'll feel good all day. This is the reason it was set for the morning.
Mel Robbins' 5-second rule can help. Start counting backward 54321 and force yourself to start at 1. If you acquire the urge to work on a goal, you must act within 5 seconds or your brain will destroy it. If you're scheduled to eat your frog at 9, eat it at 8:59. Start working.
Micro-visualisation
You've heard of visualizing to enhance the future. Visualizing a bright future won't do much if you're not prepared to focus on the now and develop the necessary habits. Alexander said:
People don’t decide their futures. They decide their habits and their habits decide their future.
I visualize the next day's schedule every morning. My day looks like this
“I’ll start writing an article at 7:30 AM. Then, I’ll get dressed up and reach the medicine outpatient department by 9:30 AM. After my duty is over, I’ll have lunch at 2 PM, followed by a nap at 3 PM. Then, I’ll go to the gym at 4…”
etc.
This reinforces the day you planned the night before. This makes following your plan easy.
Set the timer.
It's the best iPhone productivity app. A timer is incredible for increasing productivity.
Set a timer for an hour or 40 minutes before starting work. Your call. I don't believe in techniques like the Pomodoro because I can focus for varied amounts of time depending on the time of day, how fatigued I am, and how cognitively demanding the activity is.
I work with a timer. A timer keeps you focused and prevents distractions. Your mind stays concentrated because of the timer. Timers generate accountability.
To pee, I'll pause my timer. When I sit down, I'll continue. Same goes for bottle refills. To use Twitter, I must pause the timer. This creates accountability and focuses work.
Connecting everything
If you do all 4, you won't be disappointed. Here's how:
Plan out your day's schedule the night before.
Next, envision in your mind's eye the same timetable in the morning.
Speak aloud 54321 when it's time to work: Eat the frog! In the morning, devour the largest frog.
Then set a timer to ensure that you remain focused on the task at hand.
